Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of VH gene diversity in rainbow trout (Oncorhynchus mykiss): both nonsynonymous and synonymous nucleotide changes are more frequent in CDRs than in FRs.

Immunogenetics - 1 Jan 1997

Matsunaga T, Andersson E

Abstract excerpt

Forty-six immunoglobulin VH gene sequences of rainbow trout were compiled to analyze the extent of variations and the frequency of nucleotide changes in CDRs and FRs. The results show that the frequency of nonsynonymous (amino acid replacing) changes (Ka) are on average 4.9 times higher in complementarity determining regions (CDRs) than in FRs, thus contributing more diversity in CDRs. Unexpectedly, however, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Source

Identifiers

PMID: 8995187
DOI: 10.1007/s002510050190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of VH gene diversity in rainbow trout (Oncorhynchus mykiss): both nonsynonymous and synonymous nucleotide changes are more frequent in CDRs than in FRs.PMID 8995187Read ↗

Immunoglobulin variable-region diversity in the zebrafish.Semantic proximity Read ↗

Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.Semantic proximity Read ↗

Inter- and intraspecies comparison of phylogenetic fingerprints and sequence diversity of immunoglobulin variable genes.Semantic proximity Read ↗

Characterization of antibody V segment diversity in the Tasmanian devil (Sarcophilus harrisii).Semantic proximity Read ↗

Germline diversity within the mouse Igk-V9 gene family.Semantic proximity Read ↗

Predicting Regional Mutability in Antibody V Genes Based Solely on Di- and Trinucleotide Sequence CompositionSemantic proximity Read ↗

Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark.Semantic proximity Read ↗

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity.Semantic proximity Read ↗

Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.Semantic proximity Read ↗

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark.Semantic proximity Read ↗

Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.Semantic proximity Read ↗

Structure and diversity of the TCR α-chain in a teleost fishSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.