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Article

Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.

Molecular biology and evolution - 1 May 1994

Ota T, Nei M

Abstract excerpt

Immunoglobulin diversity is generated primarily by the heavy- and light-chain variable-region gene families. To understand the pattern of long-term evolution of the heavy-chain variable-region (VH) gene family, which is composed of a large number of member genes, the evolutionary relationships of representative VH genes from diverse organisms of vertebrates were studied by constructing a phylogenetic tree. This...

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PMID: 8015440
DOI: 10.1093/oxfordjournals.molbev.a040127

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