Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.

doi:10.1093/oxfordjournals.molbev.a040127

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Article

Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.

Molecular biology and evolution - 1 May 1994

Ota T, Nei M

Abstract excerpt

Immunoglobulin diversity is generated primarily by the heavy- and light-chain variable-region gene families. To understand the pattern of long-term evolution of the heavy-chain variable-region (VH) gene family, which is composed of a large number of member genes, the evolutionary relationships of...

Topics

Amino Acid Sequence
Animals
Biological Evolution
Female
Genes, Immunoglobulin
Genetic Variation
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Molecular Sequence Data
Multigene Family
Mutation
Phylogeny
Sequence Homology, Amino Acid
Vertebrates

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