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Article

Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2005

Malecek Karolina, Brandman Julie, Brodsky Jennie E, Ohta Yuko, Flajnik Martin F, Hsu Ellen

Abstract excerpt

We estimate there are approximately 15 IgM H chain loci in the nurse shark genome and have characterized one locus. It consists of one V, two D, and one J germline gene segments, and the constant (C) region can be distinguished from all of the others by a unique combination of restriction endonuclease sites in Cmu2. On the basis of these Cmu2 markers, 22 cDNA clones were selected from an epigonal organ cDNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16339548
DOI: 10.4049/jimmunol.175.12.8105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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