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Article

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark.

BMC immunology - 6 May 2004

Rumfelt Lynn L, Lohr Rebecca L, Dooley Helen, Flajnik Martin F

Abstract excerpt

BACKGROUND: Adult cartilaginous fish express three immunoglobulin (Ig) isotypes, IgM, IgNAR and IgW. Newborn nurse sharks, Ginglymostoma cirratum, produce 19S (multimeric) IgM and monomeric/dimeric IgM1gj, a germline-joined, IgM-related VH, and very low amounts of 7S (monomeric) IgM and IgNAR proteins. Newborn IgNAR VH mRNAs are diverse in the complementarity-determining region 3 (CDR3) with non-templated...

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Identifiers

PMID: 15132758
DOI: 10.1186/1471-2172-5-8
PMCID: PMC420240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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