Article
Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity.
The Journal of experimental medicine - 1 Sept 1993
Hinds-Frey K R, Nishikata H, Litman R T, Litman G W
Abstract excerpt
In Heterodontus, a phylogenetically primitive shark species, the variable (VH), diversity (DH), joining (JH) segments, and constant (CH) exons are organized in individual approximately 18-20-kb "clusters." A single large VH family with > 90% nucleic acid homology and a monotypic second gene famil...
Topics
- Animals
- Antibody Diversity
- Base Sequence
- Biological Evolution
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Sharks