Article
Comparison of different treatment regimens for the emergence of new resistance under therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2001
Roberts D E, Ribeiro R M
Abstract excerpt
OBJECTIVE: To compare the effects of different therapy regimens on the probability of emergence of new resistant mutants during therapy. METHODS: We developed a stochastic model of infection and treatment to calculate the probability of de novo resistance during therapy. We simulated diverse treatment regimens, with different efficacy in controlling HIV replication. We studied the use of genotypic testing to...
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