Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.

PLoS computational biology - 1 Mar 2009

Arora Pankhuri, Dixit Narendra M

Abstract excerpt

New antiretroviral drugs that offer large genetic barriers to resistance, such as the recently approved inhibitors of HIV-1 protease, tipranavir and darunavir, present promising weapons to avert the failure of current therapies for HIV infection. Optimal treatment strategies with the new drugs, h...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Computer Simulation
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Time Factors

Share to Virion

Share to Virus Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 19282958
DOI: 10.1371/journal.pcbi.1000305
PMCID: PMC2643484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19282958-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.PMID 19282958Read ↗

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.Semantic proximity Read ↗

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles.Semantic proximity Read ↗

Temporal Evolution of Drug Resistance to HIV Integrase Inhibitors.Semantic proximity Read ↗

Phenotypic Heterogeneity Facilitates Survival While Hindering the Evolution of Drug Resistance Due to Intraspecific CompetitionSemantic proximity Read ↗

Comprehensive mapping of the virus and host factors that guide the paths of HIV-1 escape from a therapeutic.Semantic proximity Read ↗

Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.Semantic proximity Read ↗

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressureSemantic proximity Read ↗

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneitySemantic proximity Read ↗

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity.Semantic proximity Read ↗

Development of drug resistance mutations in patients on highly active antiretroviral therapy: does competitive advantage drive evolution.Semantic proximity Read ↗

Stochastic interplay between mutation and recombination during the acquisition of drug resistance mutations in human immunodeficiency virus type 1.Semantic proximity Read ↗

A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.