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Article

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.

PLoS computational biology - 1 Mar 2009

Arora Pankhuri, Dixit Narendra M

Abstract excerpt

New antiretroviral drugs that offer large genetic barriers to resistance, such as the recently approved inhibitors of HIV-1 protease, tipranavir and darunavir, present promising weapons to avert the failure of current therapies for HIV infection. Optimal treatment strategies with the new drugs, however, are yet to be established. A key limitation is the poor understanding of the process by which HIV surmounts...

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Identifiers

PMID: 19282958
DOI: 10.1371/journal.pcbi.1000305
PMCID: PMC2643484

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