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Article

Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.

AIDS (London, England) - 1 Mar 1994

Frost S D, McLean A R

Abstract excerpt

OBJECTIVE: To investigate the roles of mutation, competition and population dynamics in the emergence of drug resistant mutants during zidovudine therapy. DESIGN: A mathematical model of the population dynamics of the viral quasispecies during zidovudine therapy was investigated. METHODS: The model was used to simulate changes in the numbers of uninfected and infected cells and the composition of the viral...

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PMID: 7913327
DOI: 10.1097/00002030-199403000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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