Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.

doi:10.1097/00002030-199403000-00005

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Article

Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.

AIDS (London, England) - 1 Mar 1994

Frost S D, McLean A R

Abstract excerpt

OBJECTIVE: To investigate the roles of mutation, competition and population dynamics in the emergence of drug resistant mutants during zidovudine therapy. DESIGN: A mathematical model of the population dynamics of the viral quasispecies during zidovudine therapy was investigated. METHODS: The mod...

Topics

CD4-Positive T-Lymphocytes
Didanosine
Drug Resistance, Microbial
Drug Therapy, Combination
Genes, pol
HIV
HIV Infections
Humans
Leukocyte Count
Models, Biological
Mutation
Population Dynamics
Species Specificity
Virus Replication
Zidovudine

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