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Article

The p75NTR mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival.

Experimental cell research - 10 Mar 2005

Allen Jeffrey, Khwaja Fatima, Byers Stephen, Djakiew Daniel

Abstract excerpt

p75NTR is most abundantly expressed in the nervous system, but is also widely expressed in many other organs and tissues where it primarily functions as a negative regulator of cell survival. In the prostate, p75NTR functions as an inhibitory protein capable of slowing proliferation and inducing apoptosis. It has been shown that p75NTR is expressed in the normal prostate, progressively lost from malignant tumor...

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Identifiers

PMID: 15707575
DOI: 10.1016/j.yexcr.2004.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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