Article
A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.
Oncogene - 8 Mar 2001
Arevalo J C, Conde B, Hempstead B I, Chao M V, Martín-Zanca D, Pérez P
Abstract excerpt
The TrkA NGF receptor extracellular region contains three leucine repeats flanked by cysteine clusters and two immunoglobulin-like domains that are required for specific ligand binding. Deletion of the immunoglobulin-like domains abolishes NGF binding and causes ligand independent activation of the receptor. Here we report a specific mutation that increases the binding affinity of the TrkA receptor for NGF. A...
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