Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

doi:10.1089/mdr.1998.4.257

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Article

Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1998

Jalal S, Wretlind B

Abstract excerpt

Principal mechanisms of bacterial resistance to quinolones are modification of target enzymes, DNA gyrase (gyrA) and topoisomerase IV (parC), or reduction of intracellular concentration due to mutations in the regulatory genes for efflux systems, such as mexR and nfxB. We have examined gyrA, parC, mexR, and nfxB genes from 16 quinolone-resistant clinical isolates of Pseudomonas aeruginosa to determine the...

Topics

Anti-Infective Agents
Bacterial Proteins
Ciprofloxacin
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II
DNA-Binding Proteins
Drug Resistance, Microbial
Fluoroquinolones
Humans
Mutation
Naphthyridines
Norfloxacin
Pseudomonas aeruginosa
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9988043
DOI: 10.1089/mdr.1998.4.257

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