Article
A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.
Biochemical and biophysical research communications - 15 Nov 1990
Ohshita Y, Hiramatsu K, Yokota T
Abstract excerpt
Two norA genes associated with hydrophilic quinolone resistance in Staphylococcus aureus were identified on the two recombinant plasmids pMR8736 and pSA209; the former was derived from a quinolone-resistant strain MR8736, and the latter was derived from a fluoroquinolone-susceptible strain 209P. We compared functions of these two genes, norA8736 and norA209 respectively, by introducing them into E. coli MC1061....
Topics
- Base Sequence
- Drug Resistance, Microbial
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Plasmids
- Quinolones
- Restriction Mapping
- Solubility
- Staphylococcus aureus