Article
Fluoroquinolone resistance in Achromobacter spp.: substitutions in QRDRs of GyrA, GyrB, ParC and ParE and implication of the RND efflux system AxyEF-OprN.
The Journal of antimicrobial chemotherapy - 19 Jan 2021
Magallon Arnaud, Roussel Mathilde, Neuwirth Catherine, Tetu Jennifer, Cheiakh Anne-Charlotte, Boulet Baptiste, Varin Véronique, Urbain Victor, Bador Julien, Amoureux Lucie
Abstract excerpt
BACKGROUND: Achromobacter are emerging pathogens in cystic fibrosis patients. Mechanisms of resistance to fluoroquinolones are unknown in clinical isolates. Among non-fermenting Gram-negative bacilli, fluoroquinolone resistance is mostly due to amino acid substitutions in localized regions of the...
Topics
- Achromobacter
- Anti-Bacterial Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Mutation