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Article

Quinolone resistance due to reduced target enzyme expression.

Journal of bacteriology - 1 Dec 2003

Ince Dilek, Hooper David C

Abstract excerpt

We report for the first time low-level quinolone resistance mediated by decreased expression of topoisomerase IV in Staphylococcus aureus. A single-step mutant of wild-type S. aureus strain ISP794, P18 selected by using twice the MIC of premafloxacin, had four- and four- to eightfold greater MICs...

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Identifiers

PMID: 14617652
DOI: 10.1128/JB.185.23.6883-6892.2003
PMCID: PMC262703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14617652-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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