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Article

In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone.

Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2016

Roychoudhury Siddhartha, Makin Kelly, Twinem Tracy, Leunk Robert, Hsu Ming Chu

Abstract excerpt

Selection of resistant strains in Streptococcus pneumoniae was studied in vitro with nemonoxacin, a novel nonfluorinated quinolone (NFQ), in comparison with quinolone benchmarks, ciprofloxacin, garenoxacin, and gatifloxacin. In stepwise resistance selection studies, a 256-fold loss of potency was...

Topics

Anti-Bacterial Agents
Ciprofloxacin
Culture Media
DNA Gyrase
DNA Topoisomerase IV
Drug Resistance, Bacterial
Fluoroquinolones
Gatifloxacin
Gene Expression
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quinolones

Sequence Analysis, DNA

Streptococcus pneumoniae

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 27267788
DOI: 10.1089/mdr.2016.0021
PMCID: PMC5073217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27267788-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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