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In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone.

Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2016

Roychoudhury Siddhartha, Makin Kelly, Twinem Tracy, Leunk Robert, Hsu Ming Chu

Abstract excerpt

Selection of resistant strains in Streptococcus pneumoniae was studied in vitro with nemonoxacin, a novel nonfluorinated quinolone (NFQ), in comparison with quinolone benchmarks, ciprofloxacin, garenoxacin, and gatifloxacin. In stepwise resistance selection studies, a 256-fold loss of potency was observed after three to four steps of exposure to ciprofloxacin or garenoxacin. In contrast, the loss of potency was...

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Identifiers

PMID: 27267788
DOI: 10.1089/mdr.2016.0021
PMCID: PMC5073217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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