Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

doi:10.1016/s0092-8674(00)81804-8

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Article

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

Cell - 13 Dec 1996

Bhat M A, Philp A V, Glover D M, Bellen H J

Abstract excerpt

We have isolated a Drosophila gene, barren (barr), required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologs in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of...

Topics

Anaphase
Animals
Cell Cycle Proteins
Cell Division
Centromere
Chromatids
Chromatin
Chromosomes
Cloning, Molecular
DNA Topoisomerases, Type II
Drosophila
Drosophila Proteins
Enzyme Activation
Genes, Insect
Humans
Immunohistochemistry
Insect Proteins
Larva

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Open in PubMed

Identifiers

PMID: 8978614
DOI: 10.1016/s0092-8674(00)81804-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8978614-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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