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Article

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

Cell - 13 Dec 1996

Bhat M A, Philp A V, Glover D M, Bellen H J

Abstract excerpt

We have isolated a Drosophila gene, barren (barr), required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologs in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister...

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PMID: 8978614
DOI: 10.1016/s0092-8674(00)81804-8

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