Article
Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.
Cell cycle (Georgetown, Tex.) - 1 Apr 2004
Torres-Rosell Jordi, Machín Félix, Jarmuz Adam, Aragón Luis
Abstract excerpt
In order to transmit a full genetic complement cells must ensure that all chromosomes are accurately split and distributed during anaphase. Chromosome XII in S. cerevisiae contains the site of nucleolar assembly, a 1-2Mb array of rDNA genes named RDN1. Cdc14p is a conserved phosphatase, essential for anaphase progression and mitotic exit, which is kept inactive at the nucleolus until mitosis. In early anaphase,...
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