Article
Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.
Molecular cell - 1 Jan 2001
Lupo R, Breiling A, Bianchi M E, Orlando V
Abstract excerpt
Mechanisms of cellular memory control the maintenance of cellular identity at the level of chromatin structure. We have investigated whether the converse is true; namely, if functions responsible for maintenance of chromosome structure play a role in epigenetic control of gene expression. We show that Topoisomerase II (TOPOII) and Barren (BARR) interact in vivo with Polycomb group (PcG) target sequences in the...
Topics
- Animals
- Body Patterning
- Cell Cycle Proteins
- Cell Nucleus
- Cells, Cultured
- Chromosome Segregation
- Chromosomes
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Gene Silencing