Article
Mitotic chromosome condensation requires Brn1p, the yeast homologue of Barren.
Molecular biology of the cell - 1 Apr 2000
Lavoie B D, Tuffo K M, Oh S, Koshland D, Holm C
Abstract excerpt
In vitro studies suggest that the Barren protein may function as an activator of DNA topoisomerase II and/or as a component of the Xenopus condensin complex. To better understand the role of Barren in vivo, we generated conditional alleles of the structural gene for Barren (BRN1) in Saccharomyces cerevisiae. We show that Barren is an essential protein required for chromosome condensation in vivo and that it is...
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