Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein.

Abstract excerpt

We describe a Drosophila maternal-effect gene, lodestar, mutations in which cause chromatin bridges at anaphase. lodestar maps to cytological position 84D13-14, and we identified the lodestar gene in germ-line transformation experiments by the ability of a genomic fragment to restore fertility to...

Topics

• Amino Acid Sequence
• Anaphase
• Animals
• Base Sequence
• Blastoderm
• Carrier Proteins
• Cell Cycle
• Chromatin
• Cloning, Molecular
• Drosophila
• Drosophila Proteins
• Embryo, Nonmammalian
• Fertility
• Male
• Molecular Sequence Data
• Mutation
• Open Reading Frames
• Recombinant Proteins