Article
Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Apr 1997
Moskaluk C A, Hruban R H, Schutte M, Lietman A S, Smyrk T, Fusaro L, Fusaro R, Lynch J, Yeo C J, Jackson C E, Lynch H T, Kern S E
Abstract excerpt
A first-degree relative with pancreatic cancer is found in 5% to 10% of patients with pancreatic carcinomas, suggesting an inherited predisposition for this neoplasm. The recently identified DPC4 tumor suppressor gene is a strong candidate for the gene responsible for the familial form of pancreatic carcinoma. DPC4 was identified in a consensus area of homozygous deletion in pancreatic carcinomas, and it is...
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