Article
Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients.
BMC cancer - 1 Sept 2010
Savva-Bordalo Joana, Ramalho-Carvalho João, Pinheiro Manuela, Costa Vera L, Rodrigues Angelo, Dias Paula C, Veiga Isabel, Machado Manuela, Teixeira Manuel R, Henrique Rui, Jerónimo Carmen
Abstract excerpt
BACKGROUND: Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). METHODS: In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR and screened DPYD for large intragenic rearrangements in peripheral blood from 45 patients with...
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