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Article

Evolution of foot-and-mouth disease virus.

Virus research - 1 Jan 2003

Domingo Esteban, Escarmís Cristina, Baranowski Eric, Ruiz-Jarabo Carmen M, Carrillo Elisa, Núñez Juan Ignacio, Sobrino Francisco

Abstract excerpt

Foot-and-mouth disease virus evolution is strongly influenced by high mutation rates and a quasispecies dynamics. Mutant swarms are subjected to positive selection, negative selection and random drift of genomes. Adaptation is the result of selective amplification of subpopulations of genomes. The extent of adaptation to a given environment is quantified by a relative fitness value. Fitness values depend on the...

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PMID: 12527437
DOI: 10.1016/s0168-1702(02)00259-9

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