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Article

Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction.

Journal of molecular biology - 15 Feb 2008

Escarmís Cristina, Lázaro Ester, Arias Armando, Domingo Esteban

Abstract excerpt

Several biological subclones of a biological clone of foot-and-mouth disease virus (FMDV) have been subjected to many plaque-to-plaque (serial bottleneck) transfers in cell culture. At transfer 190 to 409, clones underwent a transition towards a non-cytolytic (NC) phenotype in which the virus was unable to produce plaques, representing at least a 140-fold reduction in specific infectivity relative to the parental...

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Identifiers

PMID: 18158159
DOI: 10.1016/j.jmb.2007.11.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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