Variability in loss of constitutional heterozygosity across loci and among individuals: association with candidate genes in ductal breast carcinoma.

doi:10.1002/(SICI)1098-2744(199611)17:3<117::AID-MC3>3.0.CO;2-C

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Article

Variability in loss of constitutional heterozygosity across loci and among individuals: association with candidate genes in ductal breast carcinoma.

Molecular carcinogenesis - 1 Nov 1996

Rebbeck T R, Godwin A K, Buetow K H

Abstract excerpt

Genes involved in the metabolic activation or detoxification of environmental carcinogens may contribute to breast cancer susceptibility by influencing rates of somatic mutation. To examine this hypothesis, we studied the association between loss of constitutional heterozygosity (LOH) in ductal breast tumors and allelic variability in genes that regulate the metabolism of environmental carcinogens. LOH was...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Carcinoma, Ductal, Breast
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2D6
Epoxide Hydrolases
Female
Gene Deletion
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Transferase

Heterozygote

Humans

Individuality

Middle Aged

Polymorphism, Genetic

Quinone Reductases

Source

Open in PubMed

Identifiers

PMID: 8944071
DOI: 10.1002/(SICI)1098-2744(199611)17:3<117::AID-MC3>3.0.CO;2-C

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8944071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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