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Article

Allelic loss at the GPx-1 locus in cancer of the head and neck.

Biological trace element research - 1 Nov 2004

Hu Ya Jun, Dolan M Eileen, Bae Richard, Yee Herman, Roy Martin, Glickman Robert, Kiremidjian-Schumacher Lidia, Diamond Alan M

Abstract excerpt

Glutathione peroxidase is a selenium-containing, antioxidant enzyme previously implicated in the risk and development of lung and breast cancer, in part the result of allelic loss at the GPx-1 locus. This study examined allelic loss at the same locus in squamous cell carcinomas of the head and neck. The frequency of a polymorphism at codon 198 resulting in either a leucine or a proline at that position was...

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Identifiers

PMID: 15557674
DOI: 10.1385/BTER:101:2:097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Allelic loss at the GPx-1 locus in cancer of the head and neck.PMID 15557674Read ↗

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Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer.Semantic proximity Read ↗

Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.Semantic proximity Read ↗

Human glutathione peroxidase codon 198 variant increases nasopharyngeal carcinoma risk and progression.Semantic proximity Read ↗

GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.Semantic proximity Read ↗

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