Article
Loss of heterozygosity and microsatellite instability in ductal carcinoma in situ of the breast.
Cancer letters - 11 Aug 2000
Ando Y, Iwase H, Ichihara S, Toyoshima S, Nakamura T, Yamashita H, Toyama T, Omoto Y, Karamatsu S, Mitsuyama S, Fujii Y, Kobayashi S
Abstract excerpt
To investigate the alterations of genetic instabilities in carcinogenesis of the breast, we analyzed the allelotypic profile of 65 ductal carcinomas in situ (DCIS), compared with that of 207 invasive ductal carcinomas (IDC) of the breast. These studies were performed by means of examining microsatellite-length polymorphisms at seven loci (AluVpa, ESR, D11S988, D13S267, D16S398, D17S1159, and D17S855) from...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Breast Neoplasms
- Carcinoma in Situ
- Carcinoma, Ductal, Breast
- DNA, Neoplasm
- Female
- Humans
- Loss of Heterozygosity
- Microsatellite Repeats
- Middle Aged
- Paraffin Embedding