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Article

Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.

Current biology : CB - 1 Oct 1996

Betz U A, Vosshenrich C A, Rajewsky K, Müller W

Abstract excerpt

BACKGROUND: The analysis of gene function based on the generation of mutant mice by homologous recombination in embryonic stem cells is limited if gene disruption results in embryonic lethality. Mosaic mice, which contain a certain proportion of mutant cells in all organs, allow lethality to be circumvented and the potential of mutant cells to contribute to different cell lineages to be analyzed. To generate...

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PMID: 8939573
DOI: 10.1016/s0960-9822(02)70717-3

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