Article
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
Current biology : CB - 1 Oct 1996
Betz U A, Vosshenrich C A, Rajewsky K, Müller W
Abstract excerpt
BACKGROUND: The analysis of gene function based on the generation of mutant mice by homologous recombination in embryonic stem cells is limited if gene disruption results in embryonic lethality. Mosaic mice, which contain a certain proportion of mutant cells in all organs, allow lethality to be c...
Topics
- Alleles
- Animals
- Crosses, Genetic
- DNA Polymerase I
- DNA, Recombinant
- Enhancer Elements, Genetic
- Female
- Gene Deletion
- Genes, Lethal
- Genotype
- Integrases
- Intermediate Filament Proteins
- Male
- Mice
- Mice, Transgenic
- Mosaicism
- Nerve Tissue Proteins
- Nestin