Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

doi:10.1002/j.1460-2075.1994.tb06745.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

The EMBO journal - 15 Sept 1994

Williams B O, Schmitt E M, Remington L, Bronson R T, Albert D M, Weinberg R A, Jacks T

Abstract excerpt

Homozygosity for a mutation in the Rb tumor suppressor gene causes mid-gestation embryonic lethality in the mouse. Using a two-step targeting protocol, we have constructed Rb homozygous mutant mouse embryonic stem cells and used them to create chimeric animals partially composed of Rb-deficient cells. Analysis of these chimeras demonstrates widespread contribution of the mutant cells to adult tissues, including...

Topics

Adrenal Glands
Animals
Blastocyst
Erythropoiesis
Eye
Genes, Lethal
Genes, Retinoblastoma
Glucose-6-Phosphate Isomerase
Homozygote
Isoenzymes
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pituitary Gland

Pituitary Neoplasms

Retinoblastoma Protein

Stem Cells

Transplantation Chimera

Source

Open in PubMed Open full text

Identifiers

PMID: 7925270
DOI: 10.1002/j.1460-2075.1994.tb06745.x
PMCID: PMC395352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7925270-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.PMID 7925270Read ↗

Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.Semantic proximity Read ↗

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.Semantic proximity Read ↗

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.Semantic proximity Read ↗

Retinoblastoma family proteins: insights gained through genetic manipulation of mice.Semantic proximity Read ↗

Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.Semantic proximity Read ↗

Developmental defects and tumor predisposition in Rb mutant mice.Semantic proximity Read ↗

Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.Semantic proximity Read ↗

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.Semantic proximity Read ↗

Effects of an Rb mutation in the mouse.Semantic proximity Read ↗

Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.Semantic proximity Read ↗

Expression of a retinoblastoma transgene results in dwarf mice.Semantic proximity Read ↗

Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.