Article
Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II.
Molecular & general genetics : MGG - 1 Feb 1999
Litingtung Y, Lawler A M, Sebald S M, Lee E, Gearhart J D, Westphal H, Corden J L
Abstract excerpt
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II consists of tandem repeats of the consensus heptapeptide YSPTSPS. Deletion studies in tissue culture cells have indicated that the CTD plays an essential role in transcription, although the nature of this essential function remains unclear. About half of the CTD can be deleted without affecting the viability of cells in tissue culture....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.