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Article

Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic.

Journal of molecular and cellular cardiology - 1 Sept 2015

Pugach Emily K, Richmond Phillip A, Azofeifa Joseph G, Dowell Robin D, Leinwand Leslie A

Abstract excerpt

Studying the importance of genetic factors in a desired cell type or tissue necessitates the use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP mediated DNA editing and promoter-specific Cre expression, it is feasible to generate conditional knockout mice in which particular genes are disrupted in a cell type-specific manner in vivo. In cardiac myocytes, this is often...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26141530
DOI: 10.1016/j.yjmcc.2015.06.019
PMCID: PMC4558343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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