Article
WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Ioffe E, Liu Y, Bhaumik M, Poirier F, Factor S M, Stanley P
Abstract excerpt
Mutant mice produced by gene targeting in embryonic stem (ES) cells often have a complex or embryonic lethal phenotype. In these cases, it would be helpful to identify tissues and cell types first affected in mutant embryos by following the contribution to chimeras of ES cells homozygous for the...
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Line
- Chimera
- DNA
- Female
- Genes, Lethal
- Genetic Markers
- Globins
- Homozygote
- In Situ Hybridization
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mice, Transgenic
- Pregnancy