Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.

doi:10.1038/ng0297-207

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Article

Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.

Nature genetics - 1 Feb 1997

Bonyadi M, Rusholme S A, Cousins F M, Su H C, Biron C A, Farrall M, Akhurst R J

Abstract excerpt

The transforming growth factor beta 1 (TGF beta 1) signalling pathway is important in embryogenesis and has been implicated in hereditary haemorrhagic telangiectasia (HHT), atherosclerosis, tumorigenesis and immunomodulation. Therefore, identification of factors which modulate TGF beta 1 bioactiv...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Embryonic and Fetal Development
Fetal Death
Genes, Lethal
Hematopoiesis
Mice
Mice, Inbred C57BL
Mice, Knockout
Microsatellite Repeats
Phenotype
Transforming Growth Factor beta
Yolk Sac

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