Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.

Nature genetics - 1 Feb 1997

Bonyadi M, Rusholme S A, Cousins F M, Su H C, Biron C A, Farrall M, Akhurst R J

Abstract excerpt

The transforming growth factor beta 1 (TGF beta 1) signalling pathway is important in embryogenesis and has been implicated in hereditary haemorrhagic telangiectasia (HHT), atherosclerosis, tumorigenesis and immunomodulation. Therefore, identification of factors which modulate TGF beta 1 bioactivity in vivo is important. On a mixed genetic background, approximately 50% Tgfb1-/- conceptuses die midgestation from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Crosses, Genetic
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Microsatellite Repeats

Share to Phenotype

Source

Identifiers

PMID: 9020852
DOI: 10.1038/ng0297-207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.PMID 9020852Read ↗

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.Semantic proximity Read ↗

Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.Semantic proximity Read ↗

Strain dependency of TGFbeta1 function during embryogenesis.Semantic proximity Read ↗

Analysis of homozygous TGF beta 1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis.Semantic proximity Read ↗

Placentation defects are highly prevalent in embryonic lethal mouse mutants.Semantic proximity Read ↗

A murine model of hereditary hemorrhagic telangiectasiaSemantic proximity Read ↗

Absence of cardiovascular manifestations in a haploinsufficient Tgfbr1 mouse model.Semantic proximity Read ↗

Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines.Semantic proximity Read ↗

Mendelian gene identification through mouse embryo viability screeningSemantic proximity Read ↗

TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.Semantic proximity Read ↗

Death before birth: clues from gene knockouts and mutations.Semantic proximity Read ↗

The TGF beta activated kinase TAK1 regulates vascular development in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.