Article
Loss of heterozygosity at 17p13.3-ter, distal to TP53, correlates with negative hormonal phenotype in sporadic breast cancer.
Oncology reports - 1 Aug 2005
Roncuzzi Laura, Brognara Irene, Baiocchi Daniela, Amadori Dino, Gasperi-Campani Anna
Abstract excerpt
Genetic alterations on chromosome 17p are frequent in a variety of human malignancies such as sporadic breast carcinomas. The clinico-pathological significance of it remains to be elucidated. The purpose of this study was to explore whether the allelic loss (LOH) in 17p13.3, which is suggested by the presence of tumour suppressor genes, independent of TP53, are related to current clinico-pathological criteria for...
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