Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx.

doi:10.1093/jnci/88.22.1676

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Article

Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx.

Journal of the National Cancer Institute - 20 Nov 1996

Scholnick S B, Haughey B H, Sunwoo J B, el-Mofty S K, Baty J D, Piccirillo J F, Zequeira M R

Abstract excerpt

BACKGROUND: Loss of genetic heterogeneity (allelic loss or loss of heterozygosity) on chromosome arm 8p is frequent in squamous cell carcinomas of the head and neck and has been associated with poor prognosis. We have previously demonstrated that there are three minimal regions of allelic loss on...

Topics

Alleles
Carcinoma, Squamous Cell
Chromosome Deletion
Chromosomes, Human, Pair 8
DNA, Neoplasm
Disease-Free Survival
Female
Glottis
Heterozygote
Humans
Laryngeal Neoplasms
Male
Microsatellite Repeats
Middle Aged
Multivariate Analysis
Polymorphism, Genetic
Predictive Value of Tests
Prognosis

Source

Open in PubMed

Identifiers

PMID: 8931613
DOI: 10.1093/jnci/88.22.1676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8931613-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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