Article
Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival.
British journal of cancer - 1 Nov 1995
Field J K, Kiaris H, Risk J M, Tsiriyotis C, Adamson R, Zoumpourlis V, Rowley H, Taylor K, Whittaker J, Howard P
Abstract excerpt
Allelic imbalance or loss of heterozygosity (LOH) studies have been used extensively to identify regions on chromosomes that may contain putative tumour-suppressor genes. We have undertaken an extensive allelotype of 80 specimens of squamous cell carcinoma of the head and neck (SCCHN) using 145 polymorphic microsatellite markers on 39 chromosome arms. Allelic imbalances were found most frequently on chromosome...
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