Article
Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival.
British journal of cancer - 1 Nov 1995
Field J K, Kiaris H, Risk J M, Tsiriyotis C, Adamson R, Zoumpourlis V, Rowley H, Taylor K, Whittaker J, Howard P
Abstract excerpt
Allelic imbalance or loss of heterozygosity (LOH) studies have been used extensively to identify regions on chromosomes that may contain putative tumour-suppressor genes. We have undertaken an extensive allelotype of 80 specimens of squamous cell carcinoma of the head and neck (SCCHN) using 145 p...
Topics
- Alleles
- Carcinoma, Squamous Cell
- Chromosomes, Human
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Deletion
- Genetic Markers
- Head and Neck Neoplasms
- Humans
- Lymphatic Metastasis
- Microsatellite Repeats
- Neoplasm Staging
- Smoking
- Survival Analysis