Article
Clinical correlations with allelotype in supraglottic squamous cancer.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Mar 1998
Scholnick S B, El-Mofty S K, Shaw M E, Sunwoo J B, Haughey B H, Sun P C, Piccirillo J F, Zequeira M R
Abstract excerpt
Frequent allelic loss at a genetically polymorphic locus in tumors is an established marker for the presence of a tumor suppressor gene in the neighboring chromosomal region. This technique can be used to identify novel tumor suppressor genes and to monitor their status before the cloning of the gene itself. We have used the polymerase chain reaction and microsatellite loci on all 39 nonacrocentric autosomal...
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