Article
[Allele losses in squamous cell carcinomas of the larynx].
Laryngo- rhino- otologie - 1 Jan 1996
Bockmühl U, Petersen I, Dietel M
Abstract excerpt
BACKGROUND: Loss of function of tumor suppressor genes is important in the origin and progression of malignant tumors. Analysis for loss of heterozygosity (LOH) in tumors has been used to detect chromosomal regions that could harbor these genes. METHODS: We investigated 30 paired samples of tumor and normal DNA of 20 patients with laryngeal squamous cell carcinoma. Using polymerase chain reaction (PCR), we...
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