Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic loss in squamous cell carcinomas of the larynx: discordance between primary and metastatic tumors.

Genes, chromosomes & cancer - 1 Oct 1995

Sun P C, el-Mofty S K, Haughey B H, Scholnick S B

Abstract excerpt

The mutational inactivation of suppressor genes, a process required for cancer progression, generates new genetic subclones within a tumor. The allelic losses that frequently unmask these mutations serve not only as markers of the chromosomal locations of these genes but also as clonal fingerprin...

Topics

Alleles
Carcinoma, Squamous Cell
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human
DNA, Neoplasm
Gene Deletion
Genes, Tumor Suppressor
Humans
Laryngeal Neoplasms
Lymphatic Metastasis
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Identifiers

PMID: 8527396
DOI: 10.1002/gcc.2870140209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8527396-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic loss in squamous cell carcinomas of the larynx: discordance between primary and metastatic tumors.PMID 8527396Read ↗

[Allele losses in squamous cell carcinomas of the larynx].Semantic proximity Read ↗

Multiple squamous cell carcinomas of the head and neck show different phenotypes of allelic loss patterns suggesting different clonal origin of carcinogenesis.Semantic proximity Read ↗

Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx.Semantic proximity Read ↗

Allelotype of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer.Semantic proximity Read ↗

Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma.Semantic proximity Read ↗

Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma.Semantic proximity Read ↗

Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the <i>TP53</i> geneSemantic proximity Read ↗

Clinical correlations with allelotype in supraglottic squamous cancer.Semantic proximity Read ↗

Prognostic implications of loss of heterozygosity at 8p21 and 9p21 in head and neck squamous cell carcinoma.Semantic proximity Read ↗

11q23 allelic loss is associated with regional lymph node metastasis in melanoma.Semantic proximity Read ↗

Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.