Differences in the rate of DNA adduct removal and the efficiency of mutagenesis for two benzo[a]pyrene diol epoxides in CHO cells.

doi:10.1016/0165-1218(91)90042-k

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Article

Differences in the rate of DNA adduct removal and the efficiency of mutagenesis for two benzo[a]pyrene diol epoxides in CHO cells.

Mutation research - 1 Dec 1991

MacLeod M C, Daylong A, Adair G, Humphrey R M

Abstract excerpt

The initiation of carcinogenesis by carcinogens such as 7r,8t-dihydroxy-9,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I) is thought to involve the formation of DNA adducts. However, the diastereomeric diol epoxide, 7r,8t-dihydroxy-9,10c-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-II), also forms DNA adducts but is inactive in standard carcinogenesis models. We have measured the formation and loss of DNA...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Adenine Phosphoribosyltransferase
Animals
Benzopyrenes
CHO Cells
Carcinogenicity Tests
Cricetinae
DNA
DNA Adducts
DNA Repair
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epoxy Compounds

Hypoxanthine Phosphoribosyltransferase

Kinetics

Mutagenesis

Mutagenicity Tests

Mutagens

Mutation

Source

Open in PubMed

Identifiers

PMID: 1722282
DOI: 10.1016/0165-1218(91)90042-k

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APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1722282-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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