Deletion mutations in the hprt gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers.

doi:10.1093/carcin/15.7.1463

Back to search

Article

Deletion mutations in the hprt gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers.

Carcinogenesis - 1 Jul 1994

Fuscoe J C, Zimmerman L J, Harrington-Brock K, Moore M M

Abstract excerpt

The DNA sequence of 11 in vivo-arising intragenic deletion junctions occurring in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene of human T-lymphocytes was determined. These deletions ranged in size from 16 bp to 4057 bp. Extensive homology was not found at the deletion breaksites...

Topics

Adult
Base Sequence
Biomarkers
Gene Deletion
Gene Rearrangement, T-Lymphocyte
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Middle Aged
Molecular Sequence Data
Mutation
Neoplasms
T-Lymphocytes

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.