Article
An improved multipoint sib-pair analysis of quantitative traits.
Behavior genetics - 1 Sept 1996
Fulker D W, Cherny S S
Abstract excerpt
Kruglyak and Lander (1995) recently published a multipoint sib-pair procedure based on the expected distribution of zero, one and two marker alleles shared identical by descent (ibd) and the method of maximum-likelihood (ML). Their approach uses phenotypic sib-pair differences, which ignores the bivariate structure of sib-pair data. Their simulations suggested that their method was more powerful than the...
Topics
- Animals
- Genetic Markers
- Genotype
- Humans
- Likelihood Functions
- Models, Genetic
- Phenotype
- Probability