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Article

Alterations in p53 do not correlate with radioresistant DNA synthesis.

Anticancer research - 1 Jan 2000

Laderoute M P

Abstract excerpt

The radiation hypersensitivity disorder ataxia-telangiectasia (A-T) is uniquely characterized by a failure to immediately inhibit DNA synthesis in response to low dose ionizing radiation which is referred to as radioresistant DNA synthesis (RDS). As it remains controversial as to whether p53 abnormalities are central to RDS and the A-T radiation hypersensitivity disorder, post-irradiation p53 responses and cell...

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PMID: 8917392

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Alterations in p53 do not correlate with radioresistant DNA synthesis.PMID 8917392Read ↗

Post-irradiation DNA synthesis inhibition and G2 phase delay in radiosensitive body cells from non-Hodgkin's lymphoma patients: an indication of cell cycle defects.Semantic proximity Read ↗

Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.Semantic proximity Read ↗

Cellular radiosensitivity in ataxia-telangiectasia.Semantic proximity Read ↗

Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation.Semantic proximity Read ↗

Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaksSemantic proximity Read ↗

Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays.Semantic proximity Read ↗

Variation in radiation-induced apoptosis in ataxia telangiectasia lymphoblastoid cell lines.Semantic proximity Read ↗

Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines.Semantic proximity Read ↗

Complementation of chromosomal aberrations in AT/NBS hybrids: inadequacy of RDS as an endpoint in complementation studies with immortal NBS cells.Semantic proximity Read ↗

Reduced induction of P53 protein by gamma-irradiation in ataxia telangiectasia cells without constitutional mutations in exons 5, 6, 7, and 8 of the p53 gene.Semantic proximity Read ↗

Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines.Semantic proximity Read ↗

An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasiaSemantic proximity Read ↗

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