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Article

Cellular radiosensitivity in ataxia-telangiectasia.

International journal of radiation biology - 1 Dec 1994

Thacker J

Abstract excerpt

Hypersensitivity to both the cell-killing and chromosome-damaging effects of ionizing radiations, and other agents causing DNA breakage, is a consistent feature of cells from individuals with the cancer-prone disorder ataxia-telangiectasia (A-T). Evidence for a defect in DNA strand break rejoining is slight, but a higher-than-normal level of chromosomal breaks persists in irradiated A-T cells. There is also...

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Source

Identifiers

PMID: 7836857

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