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Article

Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays.

PloS one - 1 Jan 2014

Kiuru Anne, Kämäräinen Meerit, Heinävaara Sirpa, Pylkäs Katri, Chapman Kim, Koivistoinen Armi, Parviainen Teuvo, Winqvist Robert, Kadhim Munira, Launonen Virpi, Lindholm Carita

Abstract excerpt

Radiation sensitivity at low and high dose exposure to X-rays was investigated by means of chromosomal aberration (CA) analysis in heterozygous ATM mutation carrier and A-T patient (biallelic ATM mutation) lymphoblastoid cell lines (LCLs). Targeted and non-targeted responses to acutely delivered irradiation were examined by applying a co-culture system that enables study of both directly irradiated cells and...

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Identifiers

PMID: 24681528
DOI: 10.1371/journal.pone.0093211
PMCID: PMC3969311

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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