Article
Complementation of chromosomal aberrations in AT/NBS hybrids: inadequacy of RDS as an endpoint in complementation studies with immortal NBS cells.
Mutation research - 4 Apr 2001
Kraakman-van der Zwet M, Overkamp W J, Jaspers N G, Natarajan A T, Lohman P H, Zdzienicka M Z
Abstract excerpt
Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) are rare autosomal recessive hereditary disorders characterized by radiosensitivity, chromosomal instability, immunodeficiency and proneness to cancer. Although the clinical features of both syndromes are quite distinct, the cellular characteristics are very similar. Cells from both NBS and AT patients are hypersensitive to ionizing radiation (IR),...
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