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Reduced induction of P53 protein by gamma-irradiation in ataxia telangiectasia cells without constitutional mutations in exons 5, 6, 7, and 8 of the p53 gene.

Cancer genetics and cytogenetics - 1 Oct 1994

Nasrin N, Kunhi M, Einspenner M, al-Sedairy S, Hannan M

Abstract excerpt

Ataxia telangiectasia (AT) is an autosomal recessive disease of childhood with several phenotypic characteristics. One of the hallmarks of this syndrome is its hypersensitivity to ionizing radiation, which is believed to be due to defects in DNA repair/processing. In addition to radio-resistant DNA synthesis, both fibroblasts and lymphoblastoid cell lines derived from these patients have been shown to have an...

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PMID: 7923077
DOI: 10.1016/0165-4608(94)90142-2

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