Article
Reduced induction of P53 protein by gamma-irradiation in ataxia telangiectasia cells without constitutional mutations in exons 5, 6, 7, and 8 of the p53 gene.
Cancer genetics and cytogenetics - 1 Oct 1994
Nasrin N, Kunhi M, Einspenner M, al-Sedairy S, Hannan M
Abstract excerpt
Ataxia telangiectasia (AT) is an autosomal recessive disease of childhood with several phenotypic characteristics. One of the hallmarks of this syndrome is its hypersensitivity to ionizing radiation, which is believed to be due to defects in DNA repair/processing. In addition to radio-resistant D...
Topics
- Ataxia Telangiectasia
- Base Sequence
- Cell Cycle
- Cells, Cultured
- Exons
- Fibroblasts
- Flow Cytometry
- Gamma Rays
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53