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Article

Reversion of the hprt mutant clone SP5 by intrachromosomal recombination.

Carcinogenesis - 1 Apr 1992

Zhang L H, Jenssen D

Abstract excerpt

The spontaneous hprt mutant clone SP5, derived from V79 Chinese hamster cells, was shown to exhibit a duplication of approximately 2 kb, including exon 2 and its flanking intron sequences, inserted into the intron 1 sequence of the hprt gene. The most striking feature of SP5 is that this clone is quite unstable, demonstrating an extremely high spontaneous reversion frequency. Molecular analysis of 25 independent...

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PMID: 1576714
DOI: 10.1093/carcin/13.4.609

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