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Article

Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools.

Journal of molecular biology - 6 Oct 1995

Darè E, Zhang L H, Jenssen D, Bianchi V

Abstract excerpt

dCMP-deaminase-deficient V79/dC hamster cells have highly imbalanced deoxyribonucleoside triphosphate (dNTP) pools, i.e. a 17-fold larger dCTP pool, a slightly reduced dTTP and a very low dGTP pool, compared to dCMP-deaminase-proficient V79/p cells. Nevertheless, the two lines showed the same rates of spontaneous mutation at the hprt and ouabain-resistance loci. Analysis of spontaneous hprt mutations indicated an...

Topics

Animals
Cell Line
Cricetinae
Cytidine
DCMP Deaminase
DNA Replication
Deoxycytosine Nucleotides
Deoxyguanine Nucleotides
Fibroblasts
Hypoxanthine Phosphoribosyltransferase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymidine

Thymine Nucleotides

Source

Identifiers

PMID: 7563070
DOI: 10.1006/jmbi.1995.0516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7563070-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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