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Article

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.

Endocrinology - 1 May 2001

He B, Deckelbaum R A, Miao D, Lipman M L, Pollak M, Goltzman D, Karaplis A C

Abstract excerpt

PTH-related peptide (PTHrP) has been implicated in a variety of developmental and homeostatic processes. Although mice homozygous for the targeted disruption of the Pthrp gene have greatly expanded our capacity to investigate the developmental roles of the protein, the perinatal lethality of these animals has severely hindered the analysis of Pthrp's postnatal physiological effects. To overcome this obstacle, we...

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Identifiers

PMID: 11316774
DOI: 10.1210/endo.142.5.8146

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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